Azerbaijani BlogPromises of Stem Cells For Regenerative Medicine
Satellite Cells Can Be Stimulated To Repair Old Muscle More Rapidly
Satellite cells are a type of adult stem cells that can become myocytes, adipocytes or osteocytes. By becoming myocytes satellite cells help to repair injured muscle. Satellite cells do not divide as rapidly in older animals and as a result muscles do not heal as rapidly as humans and animals age. Some Stanford University School of Medicine researchers have discovered that a compound that mimicks the effect of a satellite cell regulatory protein can cause satellite cells to repair older muscles more rapidly.
In previous work, Rando found that satellite cells spring into action when a protein on the cell surface called Notch becomes activated, much like flicking the cell’s molecular “on” switch. What flips the switch is another protein called Delta, which is made on nearby cells in injured muscle. This same combination of Delta and Notch also plays a role in guiding cells through embryonic development.Source:Satellite Cells Can Be Stimulated To Repair Old Muscle More Rapidly
Myogenic Specification of Adult Stem Cells in Skeletal Muscle
To elucidate progenitor-product relationships between adult stem cells and satellite cells, we investigated the plasticity of isolated adult stem cells and satellite cells by cell culture assays. FACS-purified muscle SP cells formed hematopoietic cells in vitro but never differentiated into myocytes.
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